ОПТИМIЗАЦIЯ ХIМIОТЕРАПIЇ ЗЛОЯКIСНИХ ПУХЛИН НА ОСНОВI ДОСТАВКИ ЛIКIВ IЗ ПIДСИЛЕНОЮ КОНВЕКЦIЄЮ
DOI:
https://doi.org/10.17721/2706-9699.2022.1.06Ключові слова:
конвективна дифузiя, перенесення лiкiв, градiєнтний спускАнотація
У статтi описується чисельний метод оптимiзацiї хiмiотерапiї злоякiсних пухлин на основi доставки лiкiв за допомогою посиленої конвекцiї. Розглянуто задачу оптимального керування точковими джерелами для досягнення бажаного внутрiшньопухлинного розподiлу лiкiв у макроскопiчному масштабi, що ураховує властивостi мiжклiтинного простору i ефекти, що виникають при пiдсиленiй конвективнiй дифузiї. Показано ефективнiсть побудованого алгоритму оптимального керування.
Посилання
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